BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH PRODID:-//Missouri State University/Calendar of Events//EN CALSCALE:GREGORIAN X-WR-TIMEZONE:America/Chicago BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:DAYLIGHT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU TZNAME:CDT END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU TZNAME:CST END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:a9b2d41a-c4ea-481f-a916-e8e7124583c5.218675@calendar.missouristate.edu CREATED:20211123T171415Z LAST-MODIFIED:20211123T171415Z LOCATION: SUMMARY:PAMS Seminar: "Understanding Molecular Machines using Protein and DNA Origami Nanoarrays" by Dr. Rizal Hariadi DESCRIPTION:Dr. Rizal HariadiDepartment of Physics and the Biodesign Insti tuteArizona State University\n\n\nAbstract:The global dynamics of complex biomolecular systems arise\, in most part\, from the organization and we ak interactions of molecular machines. Programmable DNA origami\, in comb ination with conjugation strategies\, offers a unique opportunity to orga nize biomolecules (such as proteins) for applications in fundamental biol ogical physics studies and diagnostics. In this talk\, I will present our latest research demonstrating the exquisite positional control of DNA or igami technology across multiple length scales. In the first part of my t alk\, I will show two DNA-nanostructure-guided protein arrays for dissect ing collective behaviors of molecular machines consisting of 100-nm-sized rectangular DNA origami nanostructures and tens-of-micron-long DNA nanot ubes\, patterned with myosin motors. These studies uncover elegant biophy sical principles for designing force sensors and molecular transporters o n complex landscapes. In the second half of the talk\, I will present som e recent results in integrating bottom-up DNA origami nanostructures with top-down lithography for cm-scale protein nanoarrays. Finally\, I will c onclude with a discussion on the transformative potential and future dire ctions of protein and DNA nanoarrays\, including high-throughput single-m olecule biophysics measurements.\n\n\nThis seminar will be held exclusive ly on Zoom (955 5209 1021). Please visit the Physics Seminars page for a link. X-ALT-DESC;FMTTYPE=text/html:<html><head><title></title></head><body><p><b >Dr.&nbsp\;Rizal Hariadi</b><br><b>Department of&nbsp\;Physics and the Bi odesign Institute</b><br><b>Arizona State University</b></p>\n<p>Abstract :<br>The global dynamics of complex biomolecular systems arise\, in most part\, from the organization and weak interactions of molecular machines. Programmable DNA origami\, in combination with conjugation strategies\, offers a unique opportunity to organize biomolecules (such as proteins) f or applications in fundamental biological physics studies and diagnostics . In this talk\, I will present our latest research demonstrating the exq uisite positional control of DNA origami technology across multiple lengt h scales. In the first part of my talk\, I will show two DNA-nanostructur e-guided protein arrays for dissecting collective behaviors of molecular machines consisting of 100-nm-sized rectangular DNA origami nanostructure s and tens-of-micron-long DNA nanotubes\, patterned with myosin motors. T hese studies uncover elegant biophysical principles for designing force s ensors and molecular transporters on complex landscapes. In the second ha lf of the talk\, I will present some recent results in integrating bottom -up DNA origami nanostructures with top-down lithography for cm-scale pro tein nanoarrays. Finally\, I will conclude with a discussion on the trans formative potential and future directions of protein and DNA nanoarrays\, including high-throughput single-molecule biophysics measurements.</p>\n <p>This seminar will be held exclusively on Zoom (955 5209 1021). Please visit the&nbsp\;<a href="https://physics.missouristate.edu/seminars.htm"> Physics Seminars page</a> for a link.</p></body></html> DTSTART;TZID=America/Chicago:20211202T160000 DTEND;TZID=America/Chicago:20211202T170000 SEQUENCE:0 URL:https://physics.missouristate.edu/seminars.htm CATEGORIES:Public,Alumni,Current Students,Faculty,Future Students,Staff END:VEVENT END:VCALENDAR