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DTSTART:20070311T020000
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UID:ff0ae0d8-07ee-4987-b1f9-24dbf96be4cb.220536@calendar.missouristate.edu
CREATED:20220407T200509Z
LAST-MODIFIED:20220407T200509Z
LOCATION:Meyer Library\, Duane G. 101
SUMMARY:Chemistry &amp; Biochemistry Seminar: "Simplicity as the Driving Force
  for New Reaction Development: Adventures in Organofluorine Chemistry and
  Catalysis" by Dr. Socrates Munoz
DESCRIPTION:Dr. Socrates B. MunozKansas State University\n\n\n\n\n\nAbstra
 ct\n\n\nThe direct of carboxylic acids as substrates in catalytic transfo
 rmations is a highly desirable goal because of their vast structural vari
 ety\, commercial availability\, synthetic availability (great number of p
 reparative methods)\, physicochemical properties related to storage and h
 andling\, and their vast abundance in naturally occurring compounds. Most
  established synthetic transformations of carboxylic acids (catalytic or 
 otherwise) rely on the use carboxylic acid derivatives such as acyl halid
 es\, acid anhydrides\, (thio)esters and more recently\, activated twisted
  amides\, all of which must pre-synthesized from the parent carboxylic ac
 ids. Hence our efforts are being focused on the direct use of carboxylic 
 acids via in-situ activation.\n\n\nIn this context\, multiple direct cata
 lytic transformations of carboxylic acids feedstocks giving rise to (flur
 oalkyl)ketones\, aldehydes and acyl fluorides directly\, will be delineat
 ed in this presentation. Key to the success of these transformations is t
 he use of acyloxyphosphonium ions as acyl electrophiles\, readily and con
 veniently prepared in-situ from parent carboxylic acids and commodity che
 micals. The transformations proceed under exceedingly mild conditions in 
 short reaction times and exhibit notable chemoselectivity and functional 
 group compatibility. Late-stage functionalization of active pharmaceutica
 l ingredients (APIs) utilizing this approach will be also presented.
X-ALT-DESC;FMTTYPE=text/html:&lt;html&gt;&lt;head&gt;&lt;title&gt;&lt;/title&gt;&lt;/head&gt;&lt;body&gt;&lt;p&gt;&lt;s
 trong&gt;Dr. Socrates B. Munoz&lt;br&gt;Kansas State University&lt;/strong&gt;&lt;/p&gt;\n&lt;p&gt;&lt;
 strong&gt;&lt;/strong&gt;&lt;/p&gt;\n&lt;p&gt;&lt;b&gt;&lt;span&gt;Abstract&lt;/span&gt;&lt;/b&gt;&lt;span&gt;&lt;/span&gt;&lt;/p&gt;\n&lt;
 p&gt;&lt;span&gt;The&amp;nbsp\;direct of carboxylic acids as substrates in catalytic t
 ransformations is a highly desirable goal because of their vast structura
 l variety\, commercial availability\, synthetic availability (great numbe
 r of preparative methods)\, physicochemical properties related to storage
  and handling\, and their vast abundance in naturally occurring compounds
 . Most established synthetic transformations of carboxylic acids (catalyt
 ic or otherwise) rely on the use carboxylic acid derivatives such as acyl
  halides\, acid anhydrides\, (thio)esters and more recently\, activated t
 wisted amides\, all of which must pre-synthesized from the parent carboxy
 lic acids. Hence our efforts are being focused on the direct use of carbo
 xylic acids via in-situ activation.&lt;/span&gt;&lt;span&gt;&lt;/span&gt;&lt;/p&gt;\n&lt;p&gt;&lt;span&gt;In 
 this context\, multiple direct catalytic transformations of carboxylic ac
 ids feedstocks giving rise to (fluroalkyl)ketones\, aldehydes and acyl fl
 uorides directly\, will be delineated in this presentation. Key to the su
 ccess of these transformations is the use of acyloxyphosphonium ions as a
 cyl electrophiles\, readily and conveniently prepared in-situ from parent
  carboxylic acids and commodity chemicals. The transformations proceed un
 der exceedingly mild conditions in short reaction times and exhibit notab
 le chemoselectivity and functional group compatibility. Late-stage functi
 onalization of&amp;nbsp\;active pharmaceutical ingredients (APIs) utilizing t
 his approach will be also presented.&lt;/span&gt;&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;
DTSTART;TZID=America/Chicago:20220406T153500
DTEND;TZID=America/Chicago:20220406T162500
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